Winter 2021
Seunghyun (Seu) Sim is an Assistant Professor in Chemistry, Biomedical Engineering and Chemical and Biomolecular Engineering.
Our program focuses on the development of living biomaterials by integrating synthetic biology (genetic engineering) with synthetic soft materials (molecular engineering). In recent years, a myriad of genetically encoded biological modalities useful for therapeutics, imaging, sensing, and communication over various length scales have been discovered and engineered in the fields of molecular and synthetic biology. We will develop 3D-printed living composite materials (LCM) comprising immobilized, yet metabolically active, living microbial cells that perform engineered tasks. We will develop (1) LCMs producing and eluting therapeutic biomolecules in situ, as living drug delivery system, (2) microfluidic LCM devices for facile and reusable detection of biomarkers, and (3) a novel soft robotic system using controllable mechanical actuation and reconfiguration of LCMs.